Na semana de aniversário do artigo na Nature do Watson e Crick que mudou o mundo, vamos conversar sobre os principais pesquisadores e eventos que levaram a descrição da molécula de DNA. Vamos falar de Mendel e os experimentos com as ervilhas, e de Rosalind Franklin que teve a famosa foto 51 mostrada sem autorização para o Watson e logo publicou a estrutura do DNA. E o modelo proposto por Linus Pauling, qual foi o principal erro?

O Convidado desse quorum sensing é o Dr. Daniel Kumazawa do Instituto de Microbiologia da Academia de Ciência da República Tcheca.

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Lista Cronológica da história de descrição do DNA e artigos citados nesse episódio.

• March 30, 1933: Note: "The Structure of Thymus Nucleic Acid." March 30, 1933.
• Paper: Title page for "The Nature of the Chemical Bond," second edition. 1940.
• Note: "The Nature of the Intermolecular Forces Operative in Biological Processes." 1940.
• January 1944: Paper: "Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III." January 1944.
• Paper: "X-Ray Studies of Nucleic Acids." 1947.
• Paper: "Molecular Architecture and the Processes of Life." May 28, 1948.
• Picture: Oil portrait of Linus Pauling, featuring a model of the alpha-helix in the foreground. 1951.
• Paper: "Atomic coordinates and structure factors for two helical configurations of polypeptide chains." April - May 1951.
• Paper: "The structure of synthetic polypeptides." April - May 1951.
• Paper: "The pleated sheet, a new layer configuration of polypeptide chains." April - May 1951.
• Paper: "The polypeptide-chain configuration in hemoglobin and other globular proteins." April - May 1951.
• August 28, 1951
• Correspondence: Letter from J. T. Randall (FISICO QUE AJUDOU NAESTRUTURA DO DNA) to Linus Pauling. August 28, 1951.
• Correspondence: Letter from Linus Pauling to J. T. Randall. September 25, 1951.
• Picture: Diagram of the Ronwin structure for the nucleic acids. November 1951.
• Picture: George Beadle and Linus Pauling examining a skeletal model of a polypeptide chain, California Institute of Technology. 1952.
• Picture: Crystallographic photo of Sodium Thymonucleate, Type B. "Photo 51." May 1952.
• Correspondence: Letter from Alexander Todd (SENTIDO 3’ -> 5’) to Linus Pauling. May 6, 1952.
• Paper: "Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage." September 20, 1952.
• Note: "The π Helix - A Hydrogen Bonded Configuration of the Polypeptide Chain." October 30, 1952.
• November - December 1952
• Note: "A Proposed Structure for the Nucleic Acids." November - December 1952.
• Note: "Atomic Coordinates for Nucleic Acid." December 20, 1952.
• Picture: Segment of the original Watson and Crick DNA model. 1953.
• Picture: The original DNA demonstration model, designed by James Watson and Francis Crick. approx. 1953.
• Note: "A Note on Molecular Configuration in Sodium Thymonucleate." approx. 1953.
• TROCA de mensagens entre Linus Pauling e Nature
• Paper: "Structure of the nucleic acids." February 1953.
• Paper: "A proposed structure for the nucleic acids." February 1953.
• Note: "The Structure of Deoxyribose Nucleic Acid." March 17, 1953.
• April 25, 1953

Artigo de descrição da molécula de DNA

• Paper: "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid." April 25, 1953.

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